MCHR1 and obesity due to melanocortin 4 receptor deficiency: Furthermore, we show that PyRod pharmacophores present an attractive alternative to ligand‐based pharmacophores that heavily dependent on correct ligand conformations as well as their alignment, and additionally, lack information essential for further lead optimization.31 These characteristics render PyRod pharmacophores highly valuable tools for hit identification and optimization in anti‐obesity drug design campaigns against MCHR1.