MTOR and Cognitive impairment: As mTOR activity controls the phosphorylation state of proteins involved in histone post‐translational modifications and chromatin remodeling (Citro et al, 2015; Zhang et al, 2017), the sustained mTOR activation in PFC of mice exposed to THC during adolescence might also contribute to some epigenetic mechanisms underlying the development of cognitive deficits (Prini et al, 2018).