Given the deleterious influence of non‐physiological mTOR activation upon cognition in various neuropsychiatric conditions (Hoeffer & Klann, 2010; Bockaert & Marin, 2015) and its role in cognitive deficits induced by cannabis intake, we next explored whether blocking 5‐HT6 receptor‐elicited mTOR elevation in adolescent mice exposed to THC prevents the associated cognitive impairments in adulthood. This evidence concerns the gene MTOR and Cognitive impairment.