In an effort to identify signaling mechanisms underlying cognition control by the 5‐HT6 receptor, we previously demonstrated that receptor‐operated activation of mechanistic Target Of Rapamycin (mTOR) in PFC underlies cognitive deficits in two rat developmental models of schizophrenia, namely neonatal phencyclidine administration and rearing in social isolation after weaning (Meffre et al, 2012). Here, MTOR is linked to schizophrenia.