MTOR and schizophrenia: In contrast, in the present study, we showed that chronic exposure to THC during adolescence induces a sustained activation of mTOR signaling in the PFC but not in the hippocampus, reminiscent of previous observations in two neurodevelopmental models of schizophrenia, rats treated with phencyclidine at the neonatal stage or reared in social isolation after the weaning (Meffre et al, 2012).