For example, lncRNA CCAT2 was reported to boost the proliferation and migration via regulating TGF‐β signalling pathway in breast cancer.10 LncRNA AK023391 activated PI3K/Akt signalling pathway in gastric cancer and promoted cancer progression.21 LncRNA UICLM facilitated liver metastasis in colorectal cancer by targeting miRNA‐215/ZEB2 axis.22 Nonetheless, the explicit role and molecular mechanism of lncRNA PXN‐AS1 underlying GBM progression have not been explored. This evidence concerns the gene PXN-AS1 and colorectal cancer.