Combined analysis of APC, O-6-methylguanine-DNA methyltransferase (MGMT), Ras association domain family member 2 (RASSF2A), and WNT inhibitory factor 1 (Wif-1) hypermethylation was evaluated in 243 stage I–II CRC patients and demonstrated a sensitivity of 87% and a specificity of 92% (86). This evidence concerns the gene WIF1 and colorectal carcinoma.