ANXA5 and leukemia: The results demonstrated that the mag.SLPs and SLPs were highly toxic for human leukemia T cells of Jurkat line and the mechanisms of cell death induction included both the apoptosis (expression of apoptosis-related proteins, internucleosomal DNA fragmentation, and cell cycle distribution) and the necrosis (Annexin V-stained phosphatidyl serine externalization in plasma membrane and membrane rupture detected via PI staining) of the treated cells.