For example, ferric chloride treatment caused colon cancer cells to transition to a mesenchymal phenotype, with decreased e-cadherin-mediated cell-cell junctions and increased invasiveness, whereas treatment with the iron chelator DFO restored e-cadherin localization, cells then became more compact and epithelial-like and had significantly reduced invasion (136). This evidence concerns the gene CDH1 and malignant colon neoplasm.