CD44 is believed to aid in the formation of PC due to its role as an adhesion molecule by binding to the ECM protein hyaluronan.20-24 Hyaluronic acid (HA) is a natural polysaccharide composed of repeating disaccharide units of (1-3)-β linked N-acetyl-D-glucosamine and (1-4)-β linked D-glucuronic acid and has previously been coupled to nanoparticles for targeted cancer treatment 9,25-28. This evidence concerns the gene CD44 and cancer.