Lastly, a hyaluronidase‐responsive, size‐reducible nanophotosensitizer was developed by Yu and colleagues to explore the size‐dependent EPR effect.[52] They found that particles 150 nm in size, which are much bigger than those suggested by other researchers, exhibited the best tumor targeting and accumulation effects.[53] When these 150 nm‐sized nanoparticles were loaded with photosensitizer and combined with anti‐PD‐L1 blockade, they inhibited tumor growth and metastasis. The gene discussed is CD274; the disease is neoplasm.