Ni and colleagues demonstrated that locally supplied Cu2+ could hijack the estrogen metabolic pathways and promote cytotoxic superoxide and peroxide generation, whereas disassociated porphyrin can generate 1O2 through the PDT process.[45] They further showed the Cu2+‐based nMOF, when combined with anti‐PD‐L1 antibodies, not only can induce an innate immune response but can also augment the tumor‐specific adaptive response, resulting in regression in both primary and distant tumors.[45]. This evidence concerns the gene CD274 and neoplasm.