PPa is a widely used photosensitizer (PS) for photodynamic therapy (PDT).[39, 40] Meanwhile, NLG919 is a potent inhibitor of IDO‐1 for immunotherapy.[41, 42, 43] The supramolecular nanovectors actively accumulated at the tumor site via HA‐mediated recognition of CD44 overexpressed on the surface of tumor cells.[44, 45] Upon intracellular uptake, the prodrug nanovectors were activated inside the tumor cells via glutathione‐triggered cleavage of the disulfide bond of NSP or hyaluronidase‐mediated degradation of the HA backbone. Here, CD44 is linked to neoplasm.