During HAdV infection, PML‐NBs are relocalized from their typical dot‐like structure into a filamentous network, so‐called track‐like structures, induced by E4orf3 oligomerization and interaction with PML‐II isoform.62 Using this, among different HAdV species highly conserved mechanism, host factors beneficial for efficient virus infection are recruited into PML tracks. Here, PML is linked to viral infectious disease.