RNF4 and infection: Finally, PML and RAR alpha proteins are degraded by the proteasome.60, 61 We previously reported that during HAdV productive infection, RNF4 is recruited into the insoluble matrix33 and PML‐NB integrity is disrupted by relocalization into track‐like structures.62, 63 Here, we monitored PML expression during HAdV infection under ATO treatment.