786‐O is a pVHL‐deficient ccRCC cell line that constitutively expresses HIF‐2α.[43] We knocked down OTUD6B expression in these cancer cells, and examined HIF‐2α level and the activation of Akt pathways as the downstream signals of pVHL.[44] The results showed that OTUD6B depletion increased the protein level of HIF‐2α and the phosphorylation level of Akt in ACHN, H1299, and Bel7402, but not in 786‐O cells (Figure 6D, Supporting Information). This evidence concerns the gene AKT1 and nonpapillary renal cell carcinoma.