The analysis of double positive area revealed that the percentage of OTUD6B+/pVHL+ cells (9.94%) in HCC tissues was much higher than that of OTUD6B+/HIF‐1α+ cells (1.37%), OTUD6B+/VEGF+ (1.73%), and pVHL+/ HIF‐1α+ (1.13%) (Figure 6E). The gene discussed is VHL; the disease is hepatocellular carcinoma.