Using Co‐IP assays, we determined the possible effect of OTUD6B on the interaction of pVHL with Smurf1,[39] WSB1,[25] and E2‐EPF UCP.[24] As shown in Figures 5A, depletion of OTUD6B enhanced the interaction between pVHL with E2‐EPF UCP or WSB1 in HCC cells, although ectopic OTUD6B overexpression was unable to influence these interactions in cells (Figure S5A–C, Supporting Information). Here, OTUD6B is linked to hepatocellular carcinoma.