In the multivariate Cox regression analysis of OS, the result indicated that only pT stage (P = 0.039), pN stage (P < 0.001), metastasis (P = 0.001) and serum CA724 (P = 0.001) were independent prognostic factors for CRC patients with normal serum CEA levels. Here, CEACAM5 is linked to colorectal carcinoma.