Accordingly, these studies suggest that despite some observational studies indicating a direct relationship between adiponectin and higher risk of AF in a population‐based cohort (Macheret et al., 2015) and after catheter ablation in patients with paroxysmal AF (Kim et al., 2017), this peptide may modulate pathophysiological pathways in AF. The gene discussed is ADIPOQ; the disease is atrial fibrillation.