CDK4 and nasopharyngeal carcinoma: Wu, et al. found that overexpression of miR-188 blocks nasopharyngeal cancer cells in the G1 phase, through inhibiting Rb phosphorylation and down-regulates E2F transcription, and then inhibiting the mRNA and protein expression of CDK4 and CDK2, therefore enhances the radiosensitivity of nasopharyngeal carcinoma cells75.