Juan Lu et al found that miR-26a, which is down-regulated in nasopharyngeal carcinoma cells and patients, inhibits the expression of cyclin D3, CDK4 and CDK6, but activates p14 (ARF) and p21 (CIP1) in an EZH2 (enhancer of zeste 2 polycomb repressive complex 2 subunit)-dependent manner, thus induces cell cycle arrest in G1 phase and enhances radiosensitivity of nasopharyngeal carcinoma76 . This evidence concerns the gene CDKN2A and nasopharyngeal carcinoma.