Studies have shown that both down-regulated miR-23a and miR-203 in nasopharyngeal carcinoma radiotherapy-resistant cell lines (CNE-2-IR) can target IL8 and activate Stat3, which inhibits apoptosis, or AKT that affects radiotherapy resistance in nasopharyngeal carcinoma 77, 81. The gene discussed is CXCL8; the disease is nasopharyngeal carcinoma.