Wu, et al. found that overexpression of miR-188 blocks nasopharyngeal cancer cells in the G1 phase, through inhibiting Rb phosphorylation and down-regulates E2F transcription, and then inhibiting the mRNA and protein expression of CDK4 and CDK2, therefore enhances the radiosensitivity of nasopharyngeal carcinoma cells75. This evidence concerns the gene RB1 and nasopharyngeal carcinoma.