Tumour suppressor genes, or anti-oncogenes, are genes that encode proteins that suppress malignant transformation, survival and metastatic dissemination, protecting cells from becoming cancerous by preserving the integrity of cellular DNA and regulating vital cell-cycle processes in combination with the 'genome guardian', P53. Many tumour suppressor genes have been investigated, but only P53 and retinoblastoma (pRb) are widely understood. Here, TP53 is linked to neoplasm.