MAPK1 and colorectal cancer: Our previous research showed that integrin αvβ6 plays an important role in the invasiveness, metastasis, and degradation of the ECM of colorectal cancer and demonstrated that there is a direct link between extracellular signal-regulated kinase-2 (ERK2) and β6, which is essential for β6-mediated ERK2 activation and corresponding downstream effects9, 25-27.