Besides, berberine was also illustrated to promoted apoptosis of colorectal cancer via regulation of the long noncoding RNA (lncRNA) cancer susceptibility candidate 2 (CASC2)/AU-Binding Factor 1 (AUF1)/B-Cell CLL/Lymphoma 2 (Bcl-2) Axis [31]. The gene discussed is HNRNPD; the disease is cancer.