A synthetic approach [19] that combined drug target prediction, network analysis, and experimental validation indicated that Guizhi-Shaoyao-Zhimu Decoction may partially attenuate RA by means of reversing inflammation-immune system disequilibrium and regulating the HDAC1-HSP90AA1-NFKB2-IKBKB-TNF-α signaling axis. This evidence concerns the gene TNF and rheumatoid arthritis.