UBE2E3 and hematoma: In Western blot analysis, compared with the sham group, HIF-1α, VEGF and Ang-2 in the hematoma of the CSDH group increased significantly, E3 ubiquitin-protein ligase parkin, 26S proteasome and Ang-1 in the hematoma of the CSDH group decreased significantly, and the Ang-1/Ang-2 ratio decreased significantly.