Compared with the sham group, TNF-α, IL-6, and IL-10 in hematoma increased significantly in the CSDH group (TNF-α: 26.51 ± 5.35 vs 250.31 ± 26.99 pg/ml, P < 0.01; IL-6: 25.76 ± 6.39 vs 112.77 ± 6.91 pg/ml, P < 0.01; IL-10 : 17.60 ± 1.53 vs 82.76 ± 8.12 pg/ml, P < 0.01. The gene discussed is TNF; the disease is hematoma.