NLRP3 and atherosclerosis: NLRP3 inflammasome is pivotal in the stability of plaques owing to the ion flow, lysosome rupture, and ROS and endoplasmic reticulum stress mechanism, and then the NLRP3 inflammasome activation will produce mature inflammatory mediators such as IL-1β and caspase-1 which participate in the development of atherosclerosis.