Duewell et al. found that in mice lacking the inflammasome components of NLRP3, the level of IL-18-dependent NLRP3 inflammasome in atherosclerosis caused by cholesterol crystals was reduced, which provides further clear evidence to support the importance of the NLRP3 inflammasome and cholesterol crystals in the development of atherosclerosis [65]. The gene discussed is NLRP3; the disease is atherosclerosis.