IL5 and Increased total eosinophil count: Finally, our observation suggests that in asthma low β2-agonist reversibility in the presence of eosinophilia should not lead to the assumption of an irreversibility of airflow obstruction, but in contrast might be indicative of persistent eosinophilic inflammation rather than ‘remodeling’, which might predict a marked responsiveness to anti-inflammatory treatment with corticosteroids and/or anti-IL-5 treatments.