Snoek et al. (2019b) showed that three genes (GHSR, SST, and ZIC1) are important for such patients. These genes were significantly methylated in tissue specimens and cervical scrapes with increasing severity of the disease. Especially in advanced CIN2/CIN3 and squamous cell carcinoma (SCC), these genes are highly methylated (Snoek et al., 2019b). Thus, methylated GHSR, SST, and ZIC1 may serve as prognostic markers for hrHPV-positive women. This evidence concerns the gene GHSR and squamous cell carcinoma.