Krifa et al. (2013) have demonstrated the anti-cancer effect of the aqueous gall extract (G extract) of Limoniastrum guyonianum and luteolin. These two natural products downregulate UHRF1 and DNMT1 via global DNA hypomethylation and activate p16INK4A-dependent cell cycle checkpoint signaling. Thus, G extract and luteolin inhibit cervical cancer cell proliferation and induce programmed cell death (Krifa et al., 2013). However, they have only used HeLa cells in vitro. Here, CDKN2A is linked to cervical cancer.