RB1 and neoplasm: Mersakova et al. (2018) speculated that CADM1 hypermethylation leads to suppressed Rb tumor suppressor signaling, but the exact mechanism remains to be understood. Combining the methylation of CADM1, MAL, and miR124 with a positive test for hrHPV increases the specificity and sensitivity for detecting HSIL/CIN2-3 and cervical cancer. Methylation of CADM1, MAL, and miR124 may be useful in estimating the risk of transformation. However, this requires further experiments to be proven conclusively (Del Pino et al., 2019).