CXCL8 and cystic fibrosis: When analyzed for associations with IL-1 signaling and cell death, IL-8 was positively correlated with necrotic events in non-CF and CF AEC (r = 0.35, p < 0.05 and r = 0.60, p = 0.0001 respectively) (Figure 4D), and IL-1α in non-CF and CF AEC (r = 0.63 & r = 0.74 respectively; p < 0.0001) (Figure 4E).