CXCL8 and viral infectious disease: Viral infection resulted in a significant increase in IL-8 protein by both non-CF (4890.5 ± 2426.7 pg/mL vs. 15656.4 ± 4102.1 pg/mL; p < 0.05) and CF AEC (3915.3 ± 1262.1 pg/mL vs. 8762.8 ± 3919.0 pg/mL; p < 0.01) compared to relevant controls (Figure 4C), with significantly higher IL-8 produced by non-CF AEC compared to CF AEC (p < 0.05).