CrP concentrations were significantly higher in ME/CFS patients without ITO (Figure 2A), and without the risk alleles of PTPN22 rs2476601-A (Figure 2B) and CTLA4 rs3087243-G (Figure 2C and Supplementary Tables 2–4). The gene discussed is PTPN22; the disease is myalgic encephalomeyelitis/chronic fatigue syndrome.