We observed no difference in the size of the spleens from WT, RIPK3–/–, Casp-1/11–/–, and Casp-1/11–/–/RIPK3–/– DKO (double knock-out) mice at day 3 post-infection (peak of infection in the spleen) with LM-OVA (Figure 1A). Here, RIPK3 is linked to infection.