ICAM5 and infection: Although this receptor is abundantly expressed in neurons (Gahmberg et al., 2008) and shows promise for neuronal-specific tropism of neurotropic enteroviruses, the pattern of EV-D68 infection in brain slice models and microfluidic chamber motor neuron cultures does not correspond to the distribution or expression of ICAM-5 (Hixon et al., 2019a).