Examples demonstrating this are; tracking thyroid cancer metastases using the NIS (Kogai and Brent, 2012; Portulano et al., 2014), exploiting the PSMA to image prostate cancer and its spread (Perera et al., 2016; Oliveira et al., 2017), carcinoembryonic antigen (CEA) for colorectal cancer imaging (Tiernan et al., 2013), or melanin imaging in melanomas (Tsao et al., 2012). Here, CEACAM5 is linked to Familial prostate cancer.