Examples demonstrating this are; tracking thyroid cancer metastases using the NIS (Kogai and Brent, 2012; Portulano et al., 2014), exploiting the PSMA to image prostate cancer and its spread (Perera et al., 2016; Oliveira et al., 2017), carcinoembryonic antigen (CEA) for colorectal cancer imaging (Tiernan et al., 2013), or melanin imaging in melanomas (Tsao et al., 2012). The gene discussed is CEACAM5; the disease is prostate carcinoma.