Antibodies Alz50 (amino acids 5–15) and MC-1 (amino acids 312–322) tau revealed an altered conformation of tau in astroglia in tauopathies, but most of the phosphorylated-tau-positive astrocytes are not stained with the antibody tau-C3, which recognizes tau truncated at aspartic acid 421 (Ferrer et al., 2014). Here, MAPT is linked to tauopathy.