Also, BBR has been reported to suppress the androgen receptor (AR) signaling pathway (Li et al., 2011) and prostatic hyperplasia (Youn et al., 2018), and has many potential effects on PCOS (Li et al., 2013; An et al., 2014; Arentz et al., 2014; Wang et al., 2016), although the detailed mechanism remains unclear and there have been no reports on the effect of BBR on ASD development. The gene discussed is AR; the disease is benign prostatic hyperplasia.