This is the first time that the potential mechanism for PCOS-mediated ASD development has been discovered through AR-mediated ERβ suppression, providing a potential target for PCOS-mediated ASD through AR suppression (Baron-Cohen et al., 2011; Lee et al., 2017; Cherskov et al., 2018; Shay et al., 2018). Here, AR is linked to polycystic ovary syndrome.