Mice expressing the Neuroligin-3 R451C mutation exhibit autism-relevant behaviors including impaired social interaction (Tabuchi et al., 2007; Etherton et al., 2011), a heightened aggression phenotype (Burrows et al., 2015; Hosie et al., 2019), impaired communication (Chadman et al., 2008) and increased repetitive behaviors (Rothwell et al., 2014). This evidence concerns the gene NLGN3 and autism.