MAPT and tauopathy: We have recently demonstrated that the RNA-binding protein TIA1 acts as a key modulator of pathophysiology in tauopathies; specifically, reduction of TIA1 ameliorates tau related neurodegenerative processes (Vanderweyde et al., 2016; Apicco et al., 2017; Maziuk et al., 2018; Jiang et al., 2019; reviews: Ash et al., 2014; Wolozin and Ivanov, 2019).