MAPT and tauopathy: When tauopathy is the stressor, increased release of proinflammatory cytokines, likely leads to exacerbation of disease, as these mediators have been shown to increase phosphorylation of tau (Li et al., 2003; Kitazawa et al., 2005; Gorlovoy et al., 2009; Lee et al., 2010; Sy et al., 2011; Zilka et al., 2012).