Oxidative stress is an underlying driver of pathology in both human subjects and animal models of AD, with increased ROS levels correlating with increased phospho-tau load and neuronal loss (Good et al., 1996; Takeda et al., 1998; Markesbery and Carney, 1999; Markesbery, 1999; Dumont et al., 2011; Duboff et al., 2012). This evidence concerns the gene MAPT and Alzheimer disease.