TIA1 and tauopathy: We have recently demonstrated that haploinsufficiency of the RNA binding protein (RBP) T-Cell Intracellular Antigen 1 (TIA1) significantly reduces neurodegeneration in the P301S mouse model of tauopathy, however the underlying mechanism(s) of action are not known (Apicco et al., 2017; Maziuk et al., 2018; Jiang et al., 2019).