TIA1 also plays an important role in both peripheral inflammation (Piecyk et al., 2000; Cok et al., 2003; Dixon et al., 2003; Phillips et al., 2004; Kim et al., 2005; Karalok et al., 2014) and in tauopathy (Vanderweyde et al., 2016; Apicco et al., 2017; Maziuk et al., 2018; Jiang et al., 2019), but the involvement of TIA1 in CNS neuroinflammation is poorly understood (Gong and Hewett, 2018; Rayman et al., 2019). This evidence concerns the gene TIA1 and tauopathy.