Finally, if focusing on the 57 and 57 overlap genes directly connected to either APP or NRF1 in the 238-gene KeyPathwayMiner network, respectively, only one gene set, “axon guidance,” was found to be enriched for the NRF1 connected genes, while 13 gene sets were found to be enriched for the APP connected genes; these were mainly related to signal transduction, cellular processes, cancer, metabolism, and “neurotrophin signaling” (see Supplementary Table 11 in Supplementary Material 1). The gene discussed is BDNF; the disease is cancer.