The current study, built on our previous data that highlighted the reduced expression of MOCOS as a risk factor for ASD [8], reports an enthralling finding: COSMOC, an upstream antisense lncRNA located in the promoter region of MOCOS, is under-expressed in nearly all ASD patients of our cohort, the only exception being a patient affected by Asperger syndrome. The gene discussed is MOCOS; the disease is autism spectrum disorder 1.