Other cytokines such as TNF-α, TGF-β, IL-1 IL-4, IL-6, IL-8, and IL-18 are also related to the development of inflammatory pathologies involving the heart (ischemic heart disease, myocardial infarction, heart failure, and cardiomyopathies)52. The gene discussed is CXCL8; the disease is coronary artery disorder.