This mechanism of protection is directly regulated by the interaction of PTEN with CENP-C, as well as by PTEN regulating the expression of Rad51 and its influence on the double-stranded break repair machinery.39 In glioblastoma, DNA repair is attenuated after cell exposure to ionising irradiation when nuclear PTEN is phosphorylated at position 240.40 The phosphorylated PTEN binds to chromatin and recruits RAD51 to promote DNA repair. The gene discussed is PTEN; the disease is glioblastoma.