Another new study on the impact of PTEN loss in glioblastoma demonstrated increased infiltration of macrophages via the yes-associated protein 1–lysyl oxidase b1 (LOX-b1)–integrin–PYK2 axis.98 The authors showed that LOX expression activated specific pathways in macrophages that promoted their recruitment into the TME where they secrete the growth factor osteopontin (SPP1). Here, SPP1 is linked to glioblastoma.