PTEN and glioblastoma: Another new study on the impact of PTEN loss in glioblastoma demonstrated increased infiltration of macrophages via the yes-associated protein 1–lysyl oxidase b1 (LOX-b1)–integrin–PYK2 axis.98 The authors showed that LOX expression activated specific pathways in macrophages that promoted their recruitment into the TME where they secrete the growth factor osteopontin (SPP1).