Interestingly, when PTEN-deficient thyroid cancer cells were exposed to the immunomodulatory effects of metformin (which is used for treating Type 2 diabetes), there was a more pro-inflammatory phenotype in the TME.85 Such a phenotype reflects a more immunogenic TME, which presents increased infiltration of immune cells together with the synthesis of cytokines and chemokines. The gene discussed is PTEN; the disease is thyroid cancer.