Together, the CXCL8–CXCR1/2 axis mediates tumour initiation and progression, in addition to promoting neovascularisation of the TME.75 Haploinsufficiency of Pten combined with oncogenic Kras mutations was associated with NF-κB pathway activation in a mouse model of pancreatic ductal adenocarcinoma. The gene discussed is NFKB1; the disease is neoplasm.