In this manner, PTEN deficiency in combination with DDR-mutated tumours might further attenuate the levels of immune response activation due to the lack of transcription of IFN-regulated genes by IRF3.65 Cao and colleagues14 showed that cells expressing only PTEN-L synthesised the highest levels of C-X-C motif chemokine ligand (CXCL) 10 and the pro-inflammatory cytokines interleukin (IL)-6 and CXCL1. This evidence concerns the gene IRF3 and neoplasm.