While we do not know what subtype of HF is overrepresentend in DD female patients, these gender differences in HF may be explained by the presence of dysfunctional SERCA2 as it has been shown in multiple separate studies that increased oxidative stress observed in damaged myocardium lead to impairment of the SERCA pump followed by Ca2+ dyshomeostasis and prolonged diastolic relaxation, which contributed to the females’ predominent heart failure type41–43. Here, ATP2A2 is linked to heart failure.