Interestingly, with data from the TCGA database and International Cancer Genome Consortium-France (LICA-FR) and International Cancer Genome Consortium-Japan (LIRI-JP), we found that the upregulation of LGR5 expression is more pronounced in HCC tumors with β-catenin mutation (Supplementary Fig. 4). Here, LGR5 is linked to hepatocellular carcinoma.