CASP8 and leukemia: Among these components, ginsenosides have been proven to have a variety of biological activities, such as antitumor activity and improved effects on immunity.34 Molecular mechanism studies have shown that Rh2 promotes transcriptional activation of p53 and the activation of caspase 8 by upregulating downstream pro-apoptotic genes (FAS, DR4, and DR5) to induce the apoptosis of HeLa cells and human leukemia cells.