Furthermore, we also found that zA4 was significantly better at infecting THP-1 cells than the fiber chimeric adenovirus vectors Ad5/k3 and Ad5/k35 (Supplementary Fig. S3); fiber modifications are often used to increase the infectivity of Ad5 in many types of cancer cells with low CAR expression.13 Nevertheless, other types of fiber modifications (e.g., RGD insertion) can further improve the infection ability of zA4 in AML cells. Here, PSEN2 is linked to acute myeloid leukemia.