TNFSF10 and neoplasm: In addition to inducing tumor cell apoptosis, TRAIL also plays a role in immune regulation, although the impact of the TRAIL/TRAIL-R system on the immune environment of cancer is unclear.42,43 Therefore, defining the effect of TRAIL expressed on oncolytic viruses on antitumor immunity is critical for further application of TRAIL-coated oncolytic adenovirus vectors, and we will evaluate their antileukemia activity in permissive immunocompetent animal models in future studies.