Indeed, when AML cells were pretreated with Rh2 for 4 h followed by treatment with low concentrations (25 ng/mL) of sTRAIL for 16 h, cell death was significantly increased compared with that of cells treated with Rh2 or sTRAIL alone, as shown by the MTT assay (Fig. 7a). Here, RHAG is linked to acute myeloid leukemia.