For example, CD36 deletion restricts fatty acid uptake from the TME, reduces cancer-mediated lipid biosynthesis from fatty acid precursors and the generation of oncogenic lipid signaling pathways, and attenuates cancer growth, exogenous fatty acids are of equal importance as glucose for energy provision and contribute to the production of complex lipids in human prostate cancer. This evidence concerns the gene CD36 and Familial prostate cancer.