However, we found 9 known NRF2 target genes (NQO1, GCLM, AKR1C3, G6PD, UGDH, TRIM16, TRIM16L, OSGIN1, and CY924A1) that did not show any DNA methylation changes in KEAP1-mutated tumor samples. The gene discussed is KEAP1; the disease is neoplasm.