This is evidenced by the recent finding that BRAF V600E and KRAS G13D mutations in colon adenocarcinoma upregulate the transcription factors MAFG and ZNF304, respectively, resulting in targeted promoter CGI hypermethylation near the MAFG and ZNF304 binding sites [32, 33]. This evidence concerns the gene BRAF and colon adenocarcinoma.