IDH1 and astrocytoma (excluding glioblastoma): To further characterize diffusely infiltrating pontine tumors with histone H3 K27M or IDH1 R132 mutations diagnosed clinically as “aDIPG”, their genome-wide DNA methylome profiles were compared with those of H3 K27M–mutant tDIPG, DMG of the diencephalon or spinal cord, and IDH-mutant astrocytomas of the cerebral cortex by t-SNE and unsupervised cluster analyses.