CRKL has a variety of linkages for coupling to proline-rich proteins BCAR1 (breast cancer anti-estrogen resistance 1), GAB (Grb2-associated binder protein), ABL, Pax (paired boxed gene), GEF (guanine nucleotide exchange factor), C3G (3-domain-binding guanine nucleotide exchange factor), BCR (B-cell receptor)-ABL and SOS (son of sevenless) to form timely and localized complexes that are critical for cell proliferation, survival, adhesion and migration [20, 21]. This evidence concerns the gene CRKL and neoplasm.