Hepatocarcinogenesis is a very complex biological process associated with environmental risk factors and hereditary factors, including abnormal activation of Wnt/β-catenin, MAPK, AKT, and ERK signaling pathways, and the balance between activation and inactivation of proto-oncogenes and anti-oncogenes, and the differentiation of liver cancer stem cells [57]. The gene discussed is AKT1; the disease is liver cancer.