Our previous study showed that miR-429 negatively regulated CRKL expression by selectively binding to CRKL-3′-UTR at the 3728–3735 bp site by post-transcriptionally mediating CRKL’s functionality, and miR-429 suppressed the migration and invasion of HepG2 cells by targeting CRKL via inhibiting Raf/MEK/ERK (rapidly accelerated fibrosarcoma/ mitogen-activated extracellular signal-regulated kinase/ERK) pathway and EMT [26]. This evidence concerns the gene CRKL and fibrosarcoma.