While, sorafenib as a TKI could directly inhibit PDGFR and Raf, we speculate ETV6, CRKL, miR-429 might as novel biomarkers for the predication of sorafenib response in HCC, in the future study, we will clarified and validated whether ETV6, CRKL, miR-429 could predict the response of HCC to sorafenib treatment, and we expect ETV6, CRKL, miR-429 could help identify the subclass of HCC patients who would likely respond to sorafenib treatment. The gene discussed is PDGFRB; the disease is hepatocellular carcinoma.