It is mainly produced by activated macrophages, including macrophages located in adipose tissue [19], but TNF-α is also produced by various other cells, such as lymphoid cells, mast cells, endothelial cells, cardiac muscle cells, Adipocytes, fibroblasts and neurons [20].TNF-α has a wide range of biological activities and has a strong anti-tumor effect. This evidence concerns the gene TNF and neoplasm.