To date, in vivo studies on pancreatic NETs have shown efficacy towards epigenetic modulators such as bromo- and extra terminal domain (BET) inhibitors, Wnt pathway targeting β-catenin antagonists, VEGF-signalling and mammalian target of rapamycin (mTOR) antagonists [3]. The gene discussed is MTOR; the disease is pancreatic neuroendocrine tumor.