MTOR and astrocytoma (excluding glioblastoma): mTOR inhibitors (sirolimus, everolimus) are used in the clinical practice of TSC patients for the treatment of enlarging subependymal giant cell astrocytomas, renal angiomyolipomas > 4 cm, or > 3 cm and growing rapidly, symptomatic cardiac rhabdomyomas and facial angiofibromas [73].