It is definitely worthwhile to continue to study the influence of actin isoforms on FA formation and composition as the integrins, receptors of extracellular matrix (ECM) proteins and key components of FAs, are being discussed as therapeutic targets in melanoma [63] and interact with receptor tyrosine kinases [52], like epidermal growth factor receptor (EGFR) or hepatocyte growth factor receptor (c-MET), which play an important role in melanoma cells (discussed in [64]). The gene discussed is NTRK1; the disease is melanoma.