Since individuals with type 2 diabetes suffer from severe cognitive deficits [79] and deficits in hippocampal function may appear due to peripheral insulin resistance and hyperlipidemia caused by a high-calorie diet, which declines hippocampal synaptic plasticity and impairs cognitive function [80], this is a plausible reason for the significant correlation between the adiponectin/leptin ratio and the neurophysiological performance observed in the present study. Here, INS is linked to hyperlipidemia.