Immunoreactivity for PAD2, PAD3, and PAD4 was also confirmed in both sham-treated and pre-motor PD model brains, with some elevated protein levels for PAD4 observed in the pre-motor PD model, while PAD3 showed a slight elevation and PAD2 levels were not markedly changed in the pre-motor PD models (Figure 10A–C). Here, PADI3 is linked to Parkinson disease.