The study on 5xFAD mice (APPSWE, APPFlorida, APPLondon, PSEN1M146L, PSEN1L286V), in which T2DM was induced by streptozotocin, revealed that insulin deficiency changes APP processing by increasing β-site amyloid precursor protein (BACE-1) expression [57]. Here, APP is linked to type 2 diabetes mellitus.