RIPK3 and metabolic dysfunction-associated steatohepatitis: In human NAFLD/NASH biopsy samples and serum, increased RIPK3 and MLKL expressions have been described, suggesting that necroptosis may also mediate liver injury, oxidative stress, and liver fibrosis in humans, through a positive feedback loop involving the activation of Jun N-terminal kinase [2,55,73,75].