RIPK1 and cancer: In the cancer setting, over the last few years, several methods have been studied to induce necroptosis as a putative therapeutic agent: radiotherapy, classical chemotherapeutic agents (such as 5-fluorouracil), kinase inhibitors (such as dorsomorphin), death receptor ligands (such as the CD95 ligand), oncolytic viruses, metal nanoparticles, Smac mimetics (RIPK1 activators), proteasome inhibitors, obatoclax (an inhibitor of anti-apoptotic Bcl-2 proteins), and polyinosinic:polycytidylic acid (PolyI:C; a TLR3 agonist) [6].