Accordingly, in the KIF5B (Kinesin-1 heavy chain)-RET fusion, commonly found in lung carcinoma (see below), the N-terminal KIF5B backbone, containing the kinesin motor domain, was demonstrated to activate, through RAB GTPase vesicles, multiple RTKs, including EGFR and FGFR, and their downstream signaling [88]. This evidence concerns the gene EGFR and lung carcinoma.