EGFR and cholangiocarcinoma: 3’ kinase fusions are the most common; however, examples of 5’ kinase fusions have also been described, such as FGFR2 and FGFR3 (fibroblast growth factor receptors) fusions in cholangiocarcinoma and other malignancies [78] as well as the EGFR (epidermal growth factor receptor)-RAD51 (Radiation-sensitive 51) and -PURB (Purin Rich Beta) fusions in lung cancer [79].